Water Jacketed Incubator NovaIncu WT80-I

• Reliable water jacket thermal technology maintains constant temperatures for extended durations with minimal fluctuation.
• Hygiene-optimized design with seamless stainless steel interior shelves and rounded corners, simplifying decontamination.
• Robust powder-coated steel exterior ensures long-lasting durability in lab environments.
• Safety-enhanced with double doors, including a transparent tempered glass inner door.
• Smart water level alarm system prevents operation with insufficient or excess water, safeguarding the unit.
• Forced air circulation via an internal fan achieves superior temperature homogeneity.
• Equipped with a high-performance CPU and high-precision Pt sensor for accurate, stable control.
• Features programmable automation for up to 99 hours, including startup and shutdown sequences.
• Multi-point alarm system covers temperature deviations, sensor faults, and critical water levels.
• Optional upgrades include a redundant over-temperature safety cut-off and an integrated UV germicidal lamp.

Epigenetic modifications—chemical changes to DNA and histones that regulate gene expression without altering the DNA sequence—are increasingly recognized as sensitive to environmental cues.

The incubator, as the primary microenvironment for in vitro studies, must provide exceptional stability to avoid confounding these subtle studies. Researchers investigating how nutrients, toxins, or drugs influence DNA methylation or histone acetylation patterns use cell cultures. Fluctuations in pH (due to poor CO2 control) or osmolarity (due to humidity-induced evaporation) can themselves induce stress responses that alter the epigenome, creating artefactual results. Similarly, the process of cellular reprogramming (e.g., creating iPSCs) is inefficient and highly sensitive. The metabolic shift during reprogramming makes cells vulnerable to minor environmental stresses.

A stable, optimal incubator environment (precise 37°C, 5% CO2, >95% humidity) maximizes reprogramming efficiency and ensures the resulting cells have a correct epigenetic landscape. In this field, the incubator is recognized not just as a growth chamber, but as a key variable that must be tightly controlled to ensure the fidelity of epigenetic data and the quality of reprogrammed cells.